Studies on Indole Derivatives. III. : Synthesis of 3'-Phenylspiro-[2-oxoindoline-3, 5'-pyrazole]Derivatives
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چکیده
منابع مشابه
Synthesis and crystal structures of 5'-phenylspiro[indoline-3, 2'-pyrrolidin]-2-one derivatives
BACKGROUND The spiro- indole-pyrrolidine ring system is a frequently encountered structural motif in many biologically important and pharmacologically relevant alkaloids. The derivatives of spirooxindole ring systems are used as antimicrobial, antitumour agents and as inhibitors of the human NKI receptor besides being found in a number of alkaloids like horsifiline, spirotryprostatin and (+) el...
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Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...
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A wide variety of titled compounds, several of which have neuro-protecting properties has been prepared in yields ranging between 70 to 90%. The compounds were identified by 1 HNMR, 13 C NMR, 1D and 2D NOE analysis, and HRMS. An investigation of the effect of certain 5-substitutuents on the E to Z ratios in DMSO-d6 was carried out. The 5nitro and 5-acetyl substituents were not isomerized, where...
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متن کاملtert-Butyl 3-benzyl-3-[(E)-2-benzylidene-3-oxocyclopentyl]-2-oxoindoline-1-carboxylate
In the title compound, C(32)H(31)NO(4), the dihedral angles between the indoline ring and the two phenyl rings are 48.11 (9) and 66.55 (9)°. The mol-ecular conformation is stabilized by a weak intramolecular π-π stacking inter-action [centroid-centroid distance = 3.6377 (7) Å]. The crystal structure is stabilized by inter-molecular C-H⋯O hydrogen bonds, which form chains along the b axis.
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1966
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.86.12_1156